Adelina Oprean was born in Deva, Rumania. She studied at the Bucharest School of music under Stefan Gheorghiu, in Gstaad under Alberto Lysy and Yehudi Menuhin and under Sándor Végh at the Mozarteum in Salzburg.
She has won international prizes at the Bach Competition in Leipzig, at the chamber music competitions in Belgrade, Colmar and Geneva, in Eisenmatt (Joachim competition) and London (First prize Carl Flesch Competition).
From 1982 until 1986 Adelina Oprean taught at the Menhuhin Music Academy in Gstaad and assisted Sándor Végh in Lenk, since 1985 she has a professorship at the Basel School of Music.
She has performed in the whole of Europe, America, South America, and Asia as well as recording for radio and television.
Oprean is, since 1997, a permanent member of the ARIA quartet in Basel, one of Switzerland's leading quartets.